Overview
Kisspeptin-10 is the C-terminal decapeptide (Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe) of the larger KISS1 gene product, from which the biologically active kisspeptins are proteolytically derived. It belongs to the RFamide family of neuropeptides, sharing the conserved C-terminal Arg-Phe-amide motif required for receptor engagement. The decapeptide retains the receptor-binding activity of the longer kisspeptin-54 parent while offering a shorter, synthetically accessible reference sequence. It is produced synthetically for laboratory research use.
Mechanism as studied
The research literature characterizes kisspeptin-10 as an agonist at KISS1R (GPR54), a Gq/11-coupled receptor expressed on hypothalamic GnRH-producing neurons. Receptor engagement is associated with phospholipase-C activation, inositol-trisphosphate signaling, and mobilization of intracellular calcium, endpoints described in cultured neuronal and heterologous receptor systems. Preclinical studies link this signaling to depolarization of GnRH neurons and modulation of pulsatile gonadotropin-releasing-hormone output. Downstream effects on luteinizing-hormone and follicle-stimulating-hormone secretion are characterized at the level of the hypothalamic-pituitary-gonadal axis.
Research context
Contexts in which this compound appears in the in-vitro and preclinical research literature:
- Hypothalamic neuron cultures and slice electrophysiology examining GnRH-neuron depolarization and firing.
- Heterologous KISS1R expression systems measuring calcium flux and inositol-phosphate accumulation.
- Rodent models of pubertal onset and reproductive-axis regulation.
- Assays of luteinizing-hormone and follicle-stimulating-hormone release as downstream endpoints.
- Comparative pharmacology of kisspeptin-10 against longer kisspeptin-54 and kisspeptin-13 fragments.
Handling & storage
Supplied as a lyophilized powder for reconstitution in the laboratory. It is typically reconstituted with bacteriostatic water, with the diluent volume chosen to reach the working concentration a given assay requires (e.g. adding 1 mL to a 10 mg vial yields 10 mg/mL). Swirl gently to dissolve rather than shaking or vortexing, and aliquot the reconstituted solution to limit freeze-thaw cycles.
Store the sealed lyophilized vial at −20 °C protected from light, where it is stable long-term. Once reconstituted, keep refrigerated at 2–8 °C and avoid repeated freeze-thaw.
Certificates of analysis
A certificate of analysis for the current lot is in preparation and will be published in the certificate library. Lot documentation is available on request for this compound.
Order Kisspeptin-10
Lot-traceable, certificate-backed, and shipped cold-chain from the US.
For research use only
This guide is reference material for qualified researchers. The compound is an analytical-grade reference material supplied strictly for in-vitro laboratory research and development — not a drug, supplement, or medical device, and not for human or animal consumption or any therapeutic, clinical, or diagnostic use. No medical claims are made or implied.
