Overview
PT-141 (bremelanotide) is a synthetic cyclic heptapeptide and a deamidated metabolite of melanotan 2, differing from its parent principally by a C-terminal free acid in place of the primary amide. It retains the constrained lactam-ring architecture of the parent compound. Functionally it is characterized principally as an agonist at the centrally expressed melanocortin MC3R and MC4R subtypes. It is produced synthetically as a reference compound for research into central melanocortin signaling.
Mechanism as studied
The research literature characterizes PT-141 as an agonist at the centrally expressed melanocortin receptors MC3R and MC4R, which couple through Gs protein to adenylyl cyclase and cyclic-AMP generation. MC4R activation within hypothalamic circuits is the principal focus of mechanistic study. Preclinical work associates this receptor engagement with modulation of downstream central dopaminergic signaling. Its receptor selectivity and cyclization distinguish it pharmacologically from its non-selective melanocortin parent compound.
Research context
Contexts in which this compound appears in the in-vitro and preclinical research literature:
- Recombinant MC3R and MC4R systems measuring cAMP accumulation and receptor selectivity.
- Preclinical studies of hypothalamic melanocortin circuits and neuronal activation.
- Investigations of central dopaminergic signaling downstream of MC4R engagement.
- Comparative receptor pharmacology against melanotan 2 and MC1R-selective analogs.
- Radioligand-binding assays profiling affinity across melanocortin-receptor subtypes.
Handling & storage
Supplied lyophilized for laboratory reconstitution, typically in bacteriostatic water to the concentration a given assay requires (for example, 2 mL added to a 10 mg vial yields 5 mg/mL). Swirl gently to dissolve; avoid shaking or vortexing the solution. Prepare in a clean field and aliquot to limit freeze-thaw cycles.
Store sealed lyophilized vials at −20 °C protected from light for long-term stability. Keep reconstituted material refrigerated at 2–8 °C and avoid repeated freeze-thaw.
Certificates of analysis
Independent and in-house certificates published for this compound. Each reports identity and HPLC purity for the tested lot.
Order PT-141 (Bremelanotide)
Lot-traceable, certificate-backed, and shipped cold-chain from the US.
For research use only
This guide is reference material for qualified researchers. The compound is an analytical-grade reference material supplied strictly for in-vitro laboratory research and development — not a drug, supplement, or medical device, and not for human or animal consumption or any therapeutic, clinical, or diagnostic use. No medical claims are made or implied.
