Overview
DSIP (delta sleep-inducing peptide) is a nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, first isolated from the cerebral venous blood of rabbits. It is a small, water-soluble peptide produced synthetically for research use. Unlike receptor-defined neuropeptides, its specific molecular target remains incompletely characterized in the literature, and it is studied largely through its physiological and signaling correlates. It is used as a reference peptide in neuroendocrine and chronobiology research.
Mechanism as studied
The research literature characterizes DSIP through its associations rather than through a single defined receptor. Preclinical work describes modulation of hypothalamic-pituitary-adrenal (HPA) axis signaling, interactions with circadian regulatory pathways, and correlation with delta-frequency EEG activity in cortical models. Additional studies examine its influence on nociceptive signaling and its reported capacity to cross the blood-brain barrier. Its mechanism is documented at the systems and cellular level and remains an active area of characterization.
Research context
Contexts in which this compound appears in the in-vitro and preclinical research literature:
- Chronobiology models: correlation with delta-frequency EEG and circadian regulatory pathways.
- Neuroendocrine studies of hypothalamic-pituitary-adrenal (HPA) axis signaling.
- Preclinical models examining nociceptive and stress-response endpoints.
- Blood-brain-barrier permeability and peptide-transport characterization.
- Ongoing work on receptor identification and molecular-target definition.
Handling & storage
Supplied lyophilized for laboratory reconstitution, typically in bacteriostatic water to the working concentration your protocol requires (e.g. 1.5 mL into a 15 mg vial → 10 mg/mL). Add the diluent slowly down the vial wall and swirl gently; do not shake or vortex. Aliquot after reconstitution to limit freeze–thaw exposure.
Store sealed lyophilized vials at −20 °C protected from light; refrigerate reconstituted material at 2–8 °C and minimize repeated freeze–thaw cycles.
Certificates of analysis
A certificate of analysis for the current lot is in preparation and will be published in the certificate library. Lot documentation is available on request for this compound.
Order DSIP
Lot-traceable, certificate-backed, and shipped cold-chain from the US.
For research use only
This guide is reference material for qualified researchers. The compound is an analytical-grade reference material supplied strictly for in-vitro laboratory research and development — not a drug, supplement, or medical device, and not for human or animal consumption or any therapeutic, clinical, or diagnostic use. No medical claims are made or implied.
