Overview
Sermorelin is a synthetic peptide corresponding to the first 29 amino acids of human growth-hormone-releasing hormone (GHRH 1-29), the N-terminal fragment that retains the full receptor-activating capacity of the 44-residue parent hormone. Truncating the sequence to its active core preserves biological activity while simplifying synthesis. It is supplied as the acetate salt and produced synthetically as a reference GHRH analog. It belongs to the secretin/glucagon peptide superfamily.
Mechanism as studied
The research literature characterizes sermorelin as an agonist at the GHRH receptor, a class-B G-protein-coupled receptor on pituitary somatotrophs. Receptor binding couples to Gs-protein and adenylate cyclase, raising intracellular cyclic-AMP and stimulating both the synthesis and the pulsatile release of endogenous growth hormone. In preclinical models this somatotroph stimulation is associated with downstream induction of insulin-like growth factor-1 (IGF-1). Its mechanism is described at the receptor level, preserving physiological pulsatility rather than producing sustained elevation.
Research context
Contexts in which this compound appears in the in-vitro and preclinical research literature:
- Pituitary somatotroph culture: GHRH-R-coupled cAMP signaling and growth-hormone secretion.
- Preclinical models characterizing pulsatile growth-hormone release and downstream IGF-1 induction.
- Comparative pharmacology against full-length GHRH(1-44) and stabilized analogs.
- Combination studies with GH secretagogues examining convergent somatotroph signaling.
- Enzymatic-degradation and half-life characterization of the 1-29 fragment.
Handling & storage
Supplied as a lyophilized powder for laboratory reconstitution. Reconstitute with bacteriostatic water to the working concentration your assay requires (e.g. adding 1 mL to the 5 mg vial yields 5 mg/mL). Direct the diluent down the vial wall and swirl gently to dissolve; do not shake or vortex. Aliquot after reconstitution to limit freeze–thaw exposure.
Store sealed lyophilized vials at −20 °C protected from light; refrigerate reconstituted material at 2–8 °C and minimize repeated freeze–thaw.
Certificates of analysis
Independent and in-house certificates published for this compound. Each reports identity and HPLC purity for the tested lot.
Order Sermorelin Acetate
Lot-traceable, certificate-backed, and shipped cold-chain from the US.
For research use only
This guide is reference material for qualified researchers. The compound is an analytical-grade reference material supplied strictly for in-vitro laboratory research and development — not a drug, supplement, or medical device, and not for human or animal consumption or any therapeutic, clinical, or diagnostic use. No medical claims are made or implied.
