Overview
Tesamorelin is a synthetic analog of full-length human growth-hormone-releasing hormone (GHRH 1-44), modified at the N-terminus with a trans-3-hexenoyl group. This acylation increases resistance to enzymatic degradation and extends the molecule's functional stability relative to native GHRH. It is produced synthetically as a reference GHRH analog and belongs to the secretin/glucagon peptide superfamily. The stabilizing modification is a frequent focus of comparative pharmacology in the literature.
Mechanism as studied
The research literature characterizes tesamorelin as an agonist at the GHRH receptor, a class-B G-protein-coupled receptor on pituitary somatotrophs, coupled to Gs-protein/adenylate-cyclase and cyclic-AMP signaling. Receptor activation is associated with stimulation of endogenous growth-hormone synthesis and pulsatile secretion, with downstream induction of insulin-like growth factor-1 (IGF-1) in preclinical models. The literature additionally describes associated changes in lipid metabolism characterized at the cellular level. Its mechanism is documented at the receptor and cellular level while preserving physiological secretory dynamics.
Research context
Contexts in which this compound appears in the in-vitro and preclinical research literature:
- Pituitary somatotroph culture: GHRH-R-coupled cAMP signaling and growth-hormone secretion.
- Preclinical models of pulsatile growth-hormone release and downstream IGF-1 induction.
- Cellular studies characterizing associated lipid-metabolism endpoints.
- Comparative enzymatic-stability studies against native GHRH(1-44).
- Combination studies with GH secretagogues examining convergent somatotroph signaling.
Handling & storage
Supplied as a lyophilized powder for laboratory reconstitution. Reconstitute with bacteriostatic water to the working concentration your protocol requires (e.g. adding 2 mL to the 10 mg vial yields 5 mg/mL). Add diluent slowly against the vial wall and swirl gently; do not shake or vortex. Aliquot after reconstitution to minimize freeze–thaw cycles.
Store sealed lyophilized vials at −20 °C protected from light; refrigerate reconstituted material at 2–8 °C and avoid repeated freeze–thaw.
Certificates of analysis
Independent and in-house certificates published for this compound. Each reports identity and HPLC purity for the tested lot.
Order Tesamorelin
Lot-traceable, certificate-backed, and shipped cold-chain from the US.
For research use only
This guide is reference material for qualified researchers. The compound is an analytical-grade reference material supplied strictly for in-vitro laboratory research and development — not a drug, supplement, or medical device, and not for human or animal consumption or any therapeutic, clinical, or diagnostic use. No medical claims are made or implied.
