Overview
AOD-9604 is a synthetic peptide reproducing the C-terminal 176–191 residues of human growth hormone, with an added N-terminal tyrosine that improves stability. This region corresponds to the lipolytic domain of the parent hormone; the fragment was engineered to retain fat-metabolic signaling while lacking the somatogenic and diabetogenic activity of full-length growth hormone. It is studied as a reference peptide for growth-hormone-independent effects on adipose tissue.
Mechanism as studied
The research literature characterizes AOD-9604 as a modulator of adipocyte metabolism that acts independently of the growth-hormone receptor and the glucose–insulin axis. In cultured adipocyte and preclinical models, exposure is associated with stimulation of lipolysis and inhibition of lipogenesis, effects the literature has linked to β3-adrenergic-receptor signaling and downstream cyclic-AMP activity. Reported endpoints include changes in fat-oxidation gene expression without measurable change in circulating IGF-1 or blood glucose.
Research context
Contexts in which this compound appears in the in-vitro and preclinical research literature:
- Cultured adipocyte models: lipolytic and anti-lipogenic signaling endpoints.
- Rodent models of diet-induced obesity examining fat-mass and energy-metabolism markers.
- Comparative work distinguishing fragment activity from full-length growth-hormone signaling (IGF-1, glucose).
- β3-adrenergic pathway and cyclic-AMP signaling studies in fat-cell systems.
- Preclinical cartilage and chondrocyte studies referenced in the literature.
Handling & storage
Supplied as a lyophilized powder for laboratory reconstitution. Reconstitute with bacteriostatic water to the working concentration your assay requires (e.g. 1 mL into a 5 mg vial → 5 mg/mL). Add diluent slowly down the vial wall and swirl gently; do not vortex or shake. Aliquot after reconstitution to limit freeze–thaw cycles.
Store the sealed lyophilized vial at −20 °C protected from light; it is stable long-term in this state. Once reconstituted, keep refrigerated at 2–8 °C and minimize repeated freeze–thaw cycles.
Certificates of analysis
Independent and in-house certificates published for this compound. Each reports identity and HPLC purity for the tested lot.
Order AOD-9604
Lot-traceable, certificate-backed, and shipped cold-chain from the US.
For research use only
This guide is reference material for qualified researchers. The compound is an analytical-grade reference material supplied strictly for in-vitro laboratory research and development — not a drug, supplement, or medical device, and not for human or animal consumption or any therapeutic, clinical, or diagnostic use. No medical claims are made or implied.
