Overview
SLU-PP-322 is a synthetic small molecule, not a peptide, that acts as a pan-agonist of the estrogen-related receptors ERRα, ERRβ, and ERRγ — a family of orphan nuclear receptors governing programs of oxidative metabolism. It binds the receptor ligand-binding domain and stabilizes its active, coactivator-bound conformation. It is studied as a reference ERR agonist for cellular energy-metabolism research.
Mechanism as studied
The research literature characterizes SLU-PP-322 as a direct agonist that engages the ERR ligand-binding pocket and enhances recruitment of transcriptional coactivators. In cultured myotubes and preclinical models, receptor activation is associated with induction of mitochondrial-biogenesis and fatty-acid-oxidation gene programs. Reported endpoints include elevated oxidative-metabolism transcripts and increased mitochondrial respiration, with changes in running capacity described in rodent studies.
Research context
Contexts in which this compound appears in the in-vitro and preclinical research literature:
- Nuclear-receptor reporter assays characterizing ERRα/β/γ agonism.
- Cultured myotube models: mitochondrial-biogenesis and fatty-acid-oxidation gene expression.
- Rodent studies examining oxidative-metabolism markers and running capacity.
- Cellular respiration and oxygen-consumption endpoints in muscle-cell systems.
- Studies characterizing ERR agonism as an exercise-mimetic metabolic signal.
Handling & storage
Supplied as a powder for laboratory reconstitution. As a lipophilic small molecule it is typically prepared as a concentrated stock in an appropriate organic solvent (commonly DMSO) and diluted into assay buffer or media to the working concentration your protocol requires; solubility guides the choice of solvent. Mix to fully dissolve and aliquot stock solutions to limit freeze–thaw exposure.
Store the sealed vial at −20 °C protected from light. Keep solvent stock solutions frozen per your protocol, protected from moisture, and minimize repeated freeze–thaw cycles.
Certificates of analysis
Independent and in-house certificates published for this compound. Each reports identity and HPLC purity for the tested lot.
Order SLU-PP-322
Lot-traceable, certificate-backed, and shipped cold-chain from the US.
For research use only
This guide is reference material for qualified researchers. The compound is an analytical-grade reference material supplied strictly for in-vitro laboratory research and development — not a drug, supplement, or medical device, and not for human or animal consumption or any therapeutic, clinical, or diagnostic use. No medical claims are made or implied.
