Overview
BPC-157 is a synthetic 15-amino-acid sequence corresponding to a partial fragment of the human gastric juice protein BPC (Body Protection Compound). It is a stable, water-soluble peptide that does not occur naturally as an isolated fragment; the sequence is produced synthetically for research use. It is frequently studied as a reference peptide in models of endothelial and fibroblast behaviour.
Mechanism as studied
The research literature characterizes BPC-157 principally through the VEGFR2–Akt–eNOS signaling axis. In cultured endothelial systems, exposure is associated with receptor phosphorylation, nitric-oxide pathway activation, and downstream changes linked to endothelial proliferation and capillary-tube formation. Additional in-vitro work describes interaction with the FAK–paxillin pathway in fibroblast migration assays, and modulation of growth-factor receptor expression in tendon-derived cell cultures.
Research context
Contexts in which this compound appears in the in-vitro and preclinical research literature:
- Endothelial angiogenesis assays: tube-formation and migration endpoints in cultured vascular cells.
- Tendon and ligament fibroblast models: outgrowth and migration under growth-factor-receptor modulation.
- Gut-barrier and mucosal cell-culture models exploring cytoprotective signaling.
- Preclinical rodent studies referenced in the literature examining connective-tissue and vascular endpoints.
Handling & storage
Supplied as a lyophilized powder for reconstitution in the laboratory, typically with bacteriostatic water. The diluent volume is chosen to reach the working concentration required by the assay (for example, adding 2 mL to a 10 mg vial yields 5 mg/mL). Swirl gently rather than shaking to avoid shearing the peptide, prepare in a clean field, and aliquot to minimize freeze–thaw cycles.
Store the sealed lyophilized vial at −20 °C protected from light, where it is stable long-term. Once reconstituted, keep refrigerated at 2–8 °C and avoid repeated freeze–thaw.
Certificates of analysis
Independent and in-house certificates published for this compound. Each reports identity and HPLC purity for the tested lot.
Order BPC-157
Lot-traceable, certificate-backed, and shipped cold-chain from the US.
For research use only
This guide is reference material for qualified researchers. The compound is an analytical-grade reference material supplied strictly for in-vitro laboratory research and development — not a drug, supplement, or medical device, and not for human or animal consumption or any therapeutic, clinical, or diagnostic use. No medical claims are made or implied.
