Overview
KPV is the tripeptide lysyl-prolyl-valine (Lys-Pro-Val) corresponding to the C-terminal residues 11–13 of alpha-melanocyte-stimulating hormone (α-MSH). It reproduces the C-terminal message sequence of the parent hormone while lacking the core melanocortin-receptor pharmacophore responsible for pigmentary signaling. The tripeptide is water-soluble and produced synthetically for research use. It is studied as a reference peptide for anti-inflammatory signaling in epithelial and immune cell systems.
Mechanism as studied
The research literature characterizes KPV primarily as a modulator of pro-inflammatory transcription. In cultured epithelial and immune cells, exposure is associated with attenuated activation of nuclear factor-κB (NF-κB) and reduced downstream pro-inflammatory cytokine transcription. Uptake through the peptide transporter PepT1 (SLC15A1) has been described as one route by which the tripeptide reaches intracellular targets in enterocytes and immune cells. These endpoints are documented at the molecular and cellular level, independent of pigmentary melanocortin signaling.
Research context
Contexts in which this compound appears in the in-vitro and preclinical research literature:
- Epithelial and immune cell cultures: NF-κB activation and pro-inflammatory cytokine transcription endpoints.
- Peptide-transporter (PepT1) uptake studies in enterocyte models.
- Preclinical rodent models of intestinal inflammation referenced in the literature.
- Comparative work distinguishing anti-inflammatory activity from melanocortin pigmentary signaling.
- Cellular assays examining mast-cell and cytokine responses.
Handling & storage
Supplied as a lyophilized powder for reconstitution in the laboratory, typically in bacteriostatic water to the working concentration required by the assay (diluent volume set by the target mg/mL). Add diluent slowly down the vial wall and swirl gently to dissolve; do not vortex or shake. Prepare in a clean field and aliquot to minimize freeze–thaw cycles.
Store the sealed lyophilized vial at −20 °C protected from light, where it is stable long-term. Once reconstituted, keep refrigerated at 2–8 °C and avoid repeated freeze–thaw.
Certificates of analysis
Independent and in-house certificates published for this compound. Each reports identity and HPLC purity for the tested lot.
Order KPV
Lot-traceable, certificate-backed, and shipped cold-chain from the US.
For research use only
This guide is reference material for qualified researchers. The compound is an analytical-grade reference material supplied strictly for in-vitro laboratory research and development — not a drug, supplement, or medical device, and not for human or animal consumption or any therapeutic, clinical, or diagnostic use. No medical claims are made or implied.
