Overview
Cagrilintide is a synthetic, acylated long-acting analog of amylin (islet amyloid polypeptide), the peptide hormone co-secreted with insulin from pancreatic beta cells. A fatty-acid modification confers albumin binding and an extended half-life relative to native amylin, while sequence substitutions improve solubility and stability. It is studied as a dual amylin- and calcitonin-receptor agonist reference compound, and has been characterized in combination with the GLP-1 analog semaglutide.
Mechanism as studied
The research literature attributes its activity to agonism at the amylin receptors (calcitonin-receptor cores complexed with receptor-activity-modifying proteins) and the calcitonin receptor. In preclinical models, receptor activation is associated with slowed gastric emptying, promotion of satiety signaling in hindbrain and hypothalamic circuits, and reduced food intake. Comparative studies characterize additive or complementary signaling when it is combined with GLP-1-receptor agonism.
Research context
Contexts in which this compound appears in the in-vitro and preclinical research literature:
- Receptor-pharmacology assays at amylin (AMY1–3) and calcitonin receptors.
- Rodent models of diet-induced obesity examining food-intake and body-composition endpoints.
- Central satiety-circuit studies in hindbrain and hypothalamic systems.
- Combination pharmacology with GLP-1-receptor agonists such as semaglutide in preclinical models.
- Comparative half-life and receptor-kinetics work against native amylin.
Handling & storage
Supplied lyophilized for laboratory reconstitution. Reconstitute with bacteriostatic water to the concentration your protocol requires (e.g. 2 mL into a 10 mg vial → 5 mg/mL). Add diluent slowly down the vial wall and swirl gently; do not shake or vortex. Aliquot after reconstitution to limit freeze–thaw exposure.
Store sealed lyophilized vials at −20 °C, protected from light. Refrigerate reconstituted material at 2–8 °C and avoid repeated freeze–thaw.
Certificates of analysis
Independent and in-house certificates published for this compound. Each reports identity and HPLC purity for the tested lot.
Order Cagrilintide
Lot-traceable, certificate-backed, and shipped cold-chain from the US.
For research use only
This guide is reference material for qualified researchers. The compound is an analytical-grade reference material supplied strictly for in-vitro laboratory research and development — not a drug, supplement, or medical device, and not for human or animal consumption or any therapeutic, clinical, or diagnostic use. No medical claims are made or implied.
