Overview
Mazdutide (IBI362, LY3305677) is a synthetic peptide dual agonist structurally derived from oxyntomodulin, a naturally occurring gut hormone that engages both the GLP-1 and glucagon receptors. Sequence modifications and fatty-acid acylation extend its half-life relative to native oxyntomodulin while preserving balanced activity at both receptors. It is studied as a long-acting GLP-1/glucagon co-agonist reference compound.
Mechanism as studied
The research literature attributes its activity to concurrent agonism at the GLP-1 receptor and the glucagon (GCGR) receptor, both class-B G-protein-coupled receptors. In beta-cell and preclinical models, GLP-1-receptor signaling is associated with glucose-dependent insulin secretion and reduced food intake, while glucagon-receptor signaling is linked to increased hepatic and adipose energy metabolism and lipid mobilization. The literature characterizes the net metabolic profile as arising from the balance between these two pathways.
Research context
Contexts in which this compound appears in the in-vitro and preclinical research literature:
- Dual-receptor pharmacology assays at GLP-1 and glucagon receptors.
- Beta-cell culture: glucose-dependent insulinotropic signaling endpoints.
- Rodent models of diet-induced obesity examining energy-expenditure and hepatic-lipid markers.
- Comparative work against selective GLP-1 agonists and native oxyntomodulin.
- Central appetite and energy-balance circuit studies.
Handling & storage
Supplied lyophilized for laboratory reconstitution. Reconstitute with bacteriostatic water to the concentration your protocol requires (e.g. 2 mL into a 10 mg vial → 5 mg/mL). Add diluent slowly down the vial wall and swirl; do not shake. Aliquot after reconstitution to limit freeze–thaw exposure.
Store sealed lyophilized vials at −20 °C, protected from light. Reconstituted material should be refrigerated at 2–8 °C and protected from repeated freeze–thaw.
Certificates of analysis
A certificate of analysis for the current lot is in preparation and will be published in the certificate library. Lot documentation is available on request for this compound.
Order Mazdutide
Lot-traceable, certificate-backed, and shipped cold-chain from the US.
For research use only
This guide is reference material for qualified researchers. The compound is an analytical-grade reference material supplied strictly for in-vitro laboratory research and development — not a drug, supplement, or medical device, and not for human or animal consumption or any therapeutic, clinical, or diagnostic use. No medical claims are made or implied.
