Overview
KLOW is a co-packaged research set that groups four peptides supplied together: the copper tripeptide GHK-Cu (glycyl-L-histidyl-L-lysine complexed with copper(II)), the synthetic pentadecapeptide BPC-157, TB-500 (a synthetic fragment reproducing the actin-binding region of thymosin beta-4), and the tripeptide KPV (lysine-proline-valine, the C-terminal fragment of α-melanocyte-stimulating hormone). It extends the three-peptide GLOW set with KPV, adding a melanocortin-derived anti-inflammatory reference compound. Each is produced synthetically for laboratory research use and characterized individually in the literature.
Mechanism as studied
The research literature attributes distinct, complementary activities to each component. GHK-Cu is characterized as a copper-transporting ligand modulating collagen- and matrix-gene expression and metalloproteinase activity in fibroblast culture. BPC-157 is described through the VEGFR2–Akt–eNOS axis associated with endothelial proliferation and angiogenesis. TB-500 is characterized as a sequestering agent for monomeric G-actin governing cytoskeletal assembly and cell migration. KPV is described as attenuating NF-κB and pro-inflammatory-cytokine signaling downstream of melanocortin biology. The set is studied for these parallel in-vitro endpoints rather than a single unified target.
Research context
Contexts in which this compound appears in the in-vitro and preclinical research literature:
- Fibroblast cultures: collagen- and matrix-gene expression and metalloproteinase modulation attributed to GHK-Cu.
- Endothelial angiogenesis assays (tube-formation, migration) associated with BPC-157 signaling.
- Actin-polymerization and cell-migration assays characterizing TB-500 G-actin sequestration.
- Anti-inflammatory endpoints: NF-κB and cytokine modulation attributed to KPV in cultured cells.
- Combined connective-tissue and wound-model systems examining the components in parallel.
Handling & storage
Each component is supplied lyophilized and is reconstituted separately in the laboratory, typically with bacteriostatic water, to the working concentration required for its assay. Add diluent slowly down the vial wall and swirl gently to dissolve rather than vortexing; do not combine components until the protocol requires it. Aliquot each reconstituted peptide to minimize freeze–thaw exposure.
Store the sealed lyophilized vials at −20 °C protected from light, where they are stable long-term. Reconstituted material should be refrigerated at 2–8 °C and protected from repeated freeze–thaw.
Certificates of analysis
A certificate of analysis for the current lot is in preparation and will be published in the certificate library. Lot documentation is available on request for this compound.
Order KLOW Blend
Lot-traceable, certificate-backed, and shipped cold-chain from the US.
For research use only
This guide is reference material for qualified researchers. The compound is an analytical-grade reference material supplied strictly for in-vitro laboratory research and development — not a drug, supplement, or medical device, and not for human or animal consumption or any therapeutic, clinical, or diagnostic use. No medical claims are made or implied.
