Overview
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) built on the ACTH(4-10) fragment extended with a C-terminal Pro-Gly-Pro sequence that improves enzymatic stability. The Pro-Gly-Pro extension removes the corticotropic activity of the parent hormone, leaving a neuroactive fragment used as a research reference peptide.
Mechanism as studied
The research literature characterizes Semax through upregulation of brain-derived neurotrophic factor (BDNF) and its TrkB receptor in neuronal culture, alongside modulation of dopaminergic and serotonergic signaling and inhibition of enkephalin-degrading enzymes. Neuroprotective endpoints are described in cellular ischemia and oxidative-stress models.
Research context
Contexts in which this compound appears in the in-vitro and preclinical research literature:
- Neuronal cultures: BDNF/TrkB expression and downstream trophic signaling.
- Cellular ischemia and hypoxia models examining neuroprotective endpoints.
- Studies of monoaminergic modulation (dopamine and serotonin turnover).
- Peptidase-inhibition work on the endogenous enkephalin system.
Handling & storage
Supplied lyophilized for laboratory reconstitution, typically in bacteriostatic water to the working concentration required (diluent volume set by the target mg/mL). Swirl gently to dissolve, avoid vortexing, and aliquot to reduce freeze–thaw.
Store sealed vials at −20 °C away from light. Refrigerate reconstituted material at 2–8 °C and minimize freeze–thaw cycles.
Certificates of analysis
Independent and in-house certificates published for this compound. Each reports identity and HPLC purity for the tested lot.
Order Semax
Lot-traceable, certificate-backed, and shipped cold-chain from the US.
For research use only
This guide is reference material for qualified researchers. The compound is an analytical-grade reference material supplied strictly for in-vitro laboratory research and development — not a drug, supplement, or medical device, and not for human or animal consumption or any therapeutic, clinical, or diagnostic use. No medical claims are made or implied.
